I use RStudio 2024.12.0 Build 467, R version 4.4.2 Patched (2024-12-02 r87418 ucrt) under Wildows 10 Pro.
As I also use Python, I inserted the following line in my Rprofile.site file:
Sys.setenv(RETICULATE_PYTHON = "C:/Python/Python310/python.exe") which points at ms python installation.
After I did this, clicking on an extant RMd file started R studio, bur did not load the Rmd file. When I commented the "Sys.setenv ..." out, opening of RMd files worked fine again.
I have another machine running the previous version of Rstudio (and R4.1.1) and I never had this problem. I also tried a complete new installation of RStudio after inserting the Sys.setenv... line - to no avail.
I would be gratful for any advice.
Best
KS