numerical differentiation

I have a data set correponding to observations of a real valued function of two variables, that is (z,x,y), where z=f(x,y). I need to compute the cross derivative of f at the available data points, that is df/dxdy. The function gradient from the pracma package offers a solution for this question but only when the observed points (x,y) come from a regular grid.
Is there any code available to do the same with any arbitrary set of points ?
best regards

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