I wanted to make two Markov models in R. However, I am wondering if it possible to change some of the transition probabilities after a certain cycle (e.g. for cycle 14 up and until 25) in the model. Below, an example of my statement in R to create a Markov model.

For clarity, above this I defined the transition probabilities for the different combinations mentioned in the model.

```
c(p_AA, p_AB, p_AC, 0, 0, 0,
p_BA, p_BB, p_BC, p_BD, 0, 0,
p_CA, p_CB, p_CC, p_CD, p_CE, 0,
p_DA, p_DB, 0, p_DD, p_DE, 0,
0, 0, 0, 0, p_EE, p_EF,
0, 0, 0, 0, 0, 1),
byrow= TRUE,
nrow = 6, ncol = 6
)
state_names <- c("A", "B", "C", "D", "E", "F")
colnames(p_try) <- rownames(p_try) <- state_names
#creating markov model
x_init <- c(10, 0, 0, 0, 0, 0)
x_init %*% p_try
x_init %*% p_try %*% p_try
markov_chain <- function(x0, p, n_cycles = 100){
x <- matrix(NA, ncol = length(x0), nrow = n_cycles)
x <- rbind(x0, x)
colnames(x) <- colnames(p)
rownames(x) <- 0:n_cycles
for (t in 1:n_cycles){
x[t+1, ] <- x[t, ] %*% p
}
return(x)
}
x_try <- markov_chain(x_init, p_try)
```

Thanks for your help in advance!