mlflow R api for AWS storage ModuleNotFoundError: No module named 'boto3'

I don't have experience working with mlflow so I can't give you specific advice but you can install python libraries in virtual environments from R using reticulate::virtualenv_install()

After a quick look to the package documentation I can't find a mention to virtual envs but since you are using Anaconda instead of a stand alone python installation, that might be the cause of it.