Generally speaking, the regular R GUI has been easier to use for blind/low-vision users (though RStudio has been working on accessibility features, e.g. the link from @williaml).
A. Jonathan R. Godfrey (who is blind, himself) has done quite a bit of analysis on R vs. other statistical software for blind users, and written the BrailleR package (as well as a book on using it), all of which might be helpful to you.
I should note, however, that Excel wasn't part of the comparative paper I'm thinking of.
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Godfrey, A. Jonathan R., and M. Theodor Loots. 2014. “Statistical Software (R, SAS, SPSS, and Minitab) for Blind Students and Practitioners.” Journal of Statistical Software, Software Reviews 58 (1): 1–25. https://www.jstatsoft.org/v58/s01
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Godfrey, A. Jonathan R. 2013. “Statistical Software from a Blind Person’s Perspective: R Is the Best, but We Can Make It Better.” 2013. The R Journal 5 (1): 73–79. https://journal.r-project.org/archive/2013-1/godfrey.pdf
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There's a more exhaustive list of relevant work in the References section of BrailleR in Action
He also authored and maintains a page on statistical software and blind users here: https://r-resources.massey.ac.nz/StatSoftware/